Initial Results of the BURST-AF Study

Sine Wave Electroporation in Patients with Atrial Fibrillation – Initial Results of the BURST-AF Study

Results from the BURST-AF clinical trial of #ArgaMedtech's Coherent Sine Burst pulsed field ablation system were presented today at #HRS2025 by principal investigator #anteanic and simultaneously published online in Heart Rhythm Journal.

Highlights from the study included 90 patients enrolled with both paroxysmal and persistent AF. Remapping was performed at 60–120 days post-procedure in 88 patients.  

Key points:

• Single catheter solution (stylet-configurable, circular, linear and focal ablation) utilizing Sine Wave Pulsed Field Ablation for paroxysmal and persistent atrial fibrillation. 
• Lesion durability at 3 months is >98% when using optimized energy delivery and workflow recommendations.
• Outcome data at 6-months is promising, with 94.7% (PAF) and 90% (PersistentAF) patients free from recurrent atrial arrhythmias with or without anti-arrhythmic drug therapy. 

View the full manuscript at https://www.heartrhythmjournal.com/article/S1547-5271(25)02390-2/fulltext